Serena LoPiccolo-Smith

Serena LoPiccolo-Smith

Licensed Real Estate Agent / REALTOR® / Team Leader at INSPIRE Team of Keller Williams Cape Cod & The Islands member of INSPIRE Team of Keller Williams Cape Cod & The Islands
MAR: 9578048
  •   5   (31 reviews)

About Serena

Serena is a razor-sharp luxury real estate professional with a scientist’s mind and a Sicilian heart, blending precision, warmth, and determination in every transaction. She’s the kind of Realtor who steps into a Falmouth luxury listing with a trained eye for value and a quiet confidence in achieving results. No fluff, no filler, just smart strategy, tireless advocacy, and a touch of understated wit. Originally from Italy, Serena is fluent in both Italian and English, allowing her to serve Falmouth’s diverse and international clientele with ease and care. Her background as a pediatric oncologist and cancer researcher shaped her meticulous attention to detail, calm problem-solving, and clear communication style. Today, she brings that same discipline and compassion to luxury real estate in Falmouth, across Cape Cod, and throughout the South Shore. As a Seller Representative Specialist and Certified Real Estate Expert Negotiator, Serena has a deep understanding of what it takes to position luxury homes in Falmouth for success. She utilizes cutting-edge marketing strategies, advanced technology, and targeted exposure to ensure every property reaches the right audience at the right time. Known for anticipating challenges before they arise, Serena provides straightforward guidance in a market where clarity matters. Her team’s concierge division offers white-glove service for Falmouth luxury buyers and sellers alike, coordinating home improvements, managing trusted vendors, and guiding both pre-sale preparation and post-purchase enhancements with confidence and care. With an extensive professional network, refined negotiation skills, and a deep knowledge of the Falmouth luxury market, Serena consistently delivers elevated results. Serena currently serves as the Mid Cape Director for the Cape Cod & Islands Association of Realtors and as a Director on the Massachusetts Board of Realtors, reflecting her leadership and commitment to the highest professional standards. Her INSPIRE Team ranks in the top 1% of sales on the Cape Cod MLS and in the top 10% in the Keller Williams New England region, making her a trusted authority in Falmouth luxury real estate.

Serena's reviews

  5  
Serena has 31 reviewsacross 12 different locations, showing 6.
Review Serena
Seller review
Powerhouse! Serena had a buyer for us in 5 days!
2 months ago
Powerhouse! Serena had a buyer for us in 5 days!

Serena shared her wealth of knowledge and expertise as she assessed our home, created a marketing plan, and implemented it. She was creative, enthusiastic, and wonderful to work with. She is intuitive and knew just how to make things happen.

Buyer review
excellent, and very professional
over 4 years ago
excellent, and very professional

Working with Serena was a pleasure, she was professional, very knowl;edgeable and had excellent follow through. Our project was complex but she made it streamlined and manageable. Most importantly, we ended up with the exact result that we wanted.

Buyer review
The INSPIRE team is hands down the best Real Estate team on Cape Cod
over 4 years ago
The INSPIRE team is hands down the best Real Estate team on Cape Cod

The INSPIRE team is hands down the best Real Estate team on Cape Cod. Serena LoPiccolo-Smith helped us navigate through the post pandemic housing market and purchase our dream home! Serena made sure to meet with us regularly and her attention to detail and knowledge of the market is unmatched. Serena was extremely helpful, open, transparent, and reliable through the whole process, she really cared about us, and understood our needs from the very first meeting. I would recommend Serena and the INSPIRE team to anyone! We can not thank you enough for your hard work and dedication!

Seller review
Outstanding!
over 4 years ago
Outstanding!

We have worked with Serena on several properties. She is a true professional.

Seller review
Then, out of the blue, we got a call from you!
over 4 years ago
Then, out of the blue, we got a call from you!

Dear Serena, We had tried to sell our home in West Falmouth through another broker and had no offers, so we rented it out for a year. During that year (and the housing bubble) we heard from a number of interested realtors who wanted to list the house, but when we explained that it was rented and offered to consider any offers that allowed the renters to stay until their year was over, we heard nothing. Then, out of the blue, we got a call from you! You had an interested couple, and over a very short period of time you managed the process of setting up a P&S agreement despite the renter and the complexity of a VA loan. Over the next months, you facilitated all the pieces required to make the sale a reality. This was a complex process, but you managed the assessment, inspection, and more. Finally, as we neared the final sale, we learned that additional work would be required on the exterior to satisfy the VA assessor. Not only did you manage that process but you paid for it! Thanks so much for your ongoing attention to all the details required for this sale. We are thrilled, and I know our buyers are delighted. All the best, Lisa Rudy and Peter Cook

Seller review
Congratulations to all !!
A big shout out  to Serena , and the  whole Inspire Team for making my dre
over 4 years ago
Congratulations to all !! A big shout out to Serena , and the whole Inspire Team for making my dre

Congratulations to all !! A big shout out to Serena , and the whole Inspire Team for making my dream to sell my house come true. I want to thank Serena , for her knowledge , and dedication and her continued support she gave me throughout this process. Selling my home has been a bittersweet decision. However, I do find comfort in knowing that a beautiful family has purchased the home , and will raise their family. Thank you … Natalie Faria

Show all 31 reviews

Serena's properties

Serena has 7 properties for sale and sold 37 properties in the last 12 months, showing 4, sorted by most recent activity

For Sale
$725,000
51 Jamies Path
Plymouth MA 02360
3
3
6
Single-Family
Listing courtesy of Keller Williams Realty - Cape Cod and the Islands
For Sale
$725,000
51 Jamie's Path
Plymouth MA 02360
3
3
6
Single-Family
Listing courtesy of Keller Williams Realty - Cape Cod and the Islands
SoldMay 8, 2026
$900,000
12 Dove's Wing Road
South Yarmouth MA 02664
3
3
6
Single-Family
Listing courtesy of Keller Williams Realty - Cape Cod and the Islands and ERA Cape Real Estate, LLC
SoldMay 7, 2026
$950,000
61 Wintergreen Rd
Seabrook MA 02649
3
3
3
Single-Family
Listing courtesy of Keller Williams Realty - Cape Cod and the Islands
Show all 44 properties
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